NDUFC1 — NADH:ubiquinone oxidoreductase subunit C1
NDUFC1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NDUFC1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Chromatin Remodeling DNA/chromatin regulation | ANP32B, ATP5IF1, CALM3, CBX3, COMMD4, HAT1, HMGA1, HMGB1 +9 more | View in SCUBA |
| CD8⁺ T cells | Autophagy Metabolic Stress Stress | CREM, CTSC, DNAJB6, DOK2, EFHD2, GNG2, ICOS, MAP1LC3B +2 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, COX7A2L, DNAJC7, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36 +11 more | |
| Goblet cells | Oxidative Phosphorylation Mitochondrial & OxPhos | ATP5MF, COX7A2, COX7B, COX8A, CYCS, MPC1, MPC2, NDUFC2 +3 more | View in SCUBA |
| Lymphatic endothelial | Mitochondrial OxPhos Complex Mitochondrial & OxPhos | ANAPC11, AP2M1, BRK1, LSM3, MRPL51, MRPS21, NDUFA12, NDUFAB1 +6 more | View in SCUBA |
| Macrophages | Mitochondrial Complex Assembly Mitochondrial & OxPhos | COX14, LAMTOR1, MRPL43, NDUFA8, SMIM26, SURF1, TADA3, VPS28 | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Biogenesis & Folding Housekeeping | ADH5, CCT3, CTDSP1, FAM117A, FKBP1A, FKBP8, LSM4, MAT2B +6 more |
About the gene
| Synonyms | KFYI |
|---|---|
| Chromosome | 4: 139266880-139302551 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Metabolic proteins, Predicted membrane proteins |
| Biological process | Electron transport, Respiratory chain, Transport |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.