Basal Maintenance Genes
Gene co-expression module in Smooth muscle cells
| Category | Housekeeping |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hubs PPP1CB (protein phosphatase 1 catalytic subunit, also the myosin-phosphatase catalytic core) and CCNI (constitutively expressed cyclin I) sit with COX8A/COX14 (cytochrome c oxidase assembly/subunit), MRPL33 (mitoribosome), SOD1, ANAPC16, VAMP2, TSPYL1, C7orf50 and HNRNPA1 — a set of moderately expressed, ubiquitous maintenance genes with no unifying pathway. Uniform expression across subsets and tight co-expression with the other housekeeping neighbors (M86, M101) indicates a general basal transcript-abundance module rather than cell cycle (CCNI and ANAPC16 are not proliferation-restricted).
Genes
ANAPC16, C1QTNF2, C7orf50, CCNI, COX14, COX8A, HNRNPA1, MRPL33, PPP1CB, SOD1, TSPYL1, VAMP2
Most correlated modules
- OxPhos & Translation · correlation 0.89
- OXPHOS Complex I · correlation 0.88
- Ubiquitous Housekeeping Transcripts · correlation 0.87
- Respiratory Chain Subunits · correlation 0.86
- Myogenic Cytoskeletal Program · correlation 0.85
- Oxidative Muscle Metabolism · correlation 0.85
- Calcium Handling Contractile · correlation 0.84
- Basal Metabolic Housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.