TADA3 — Transcriptional adaptor 3
TADA3 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TADA3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Metabolic Housekeeping Housekeeping | COX17, DAZAP1, EIF4E, ILF2, MRPL51, NDUFA2, SSNA1, TPM4 | View in SCUBA |
| Gamma-delta T cells | Actin Remodeling Cytoskeletal | AP1M1, APOBEC3C, ATP5PB, CAP1, CAPN1, CAPZB, DBNL, LSP1 +10 more | |
| Macrophages | Mitochondrial Complex Assembly Mitochondrial & OxPhos | COX14, LAMTOR1, MRPL43, NDUFA8, NDUFC1, SMIM26, SURF1, VPS28 | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Complex Regulation DNA/chromatin regulation | APEH, CAPZB, CCND2, CFH, CHTF8, ESYT1, GDI2, HACD4 +9 more |
About the gene
| Synonyms | ADA3, FLJ20221, FLJ21329, hADA3, NGG1, TADA3L |
|---|---|
| Chromosome | 3: 9779967-9793011 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53- dependent transcriptional activation. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.