ANAPC16 — Anaphase promoting complex subunit 16
ANAPC16 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANAPC16's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Repair Housekeeping Housekeeping | CCDC85B, CDIP1, CKLF, COTL1, DNAJC4, ECH1, ERCC1, IFT27 +10 more | |
| Innate lymphoid cells | Protein Biogenesis & Import Protein processing & ER | ATP6AP2, CD164, COMMD6, EEF1D, KLRB1, NACA, PFDN5, S100A4 +6 more | View in SCUBA |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ALDH2, BCL7C, CAVIN2, CCL21, CD320, CRACR2B, FXYD6, GUSB +10 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Tissue Residence Tissue residence | ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, CXCR6, ECH1 +7 more | |
| Smooth muscle cells | Basal Maintenance Genes Housekeeping | C1QTNF2, C7orf50, CCNI, COX14, COX8A, HNRNPA1, MRPL33, PPP1CB +3 more | View in SCUBA |
About the gene
| Synonyms | APC16, bA570G20.3, C10orf104, CENP-27, FLJ33728 |
|---|---|
| Chromosome | 10: 72216000-72235860 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Cell cycle, Cell division, Mitosis, Ubl conjugation pathway |
Function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.