CTPS1 — CTP synthase 1
CTPS1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTPS1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Ubiquitin DNA/chromatin regulation | ACBD3, CDADC1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1, RCOR1 +7 more | |
| Mucosal-associated invariant T cell | Autophagy & Trafficking Stress | ATG2A, B3GNT2, BEST1, CEBPZ, ELOA, KANSL2, LITAF, MTFP1 +6 more |
About the gene
| Synonyms | CTPS, GATD5A |
|---|---|
| Chromosome | 1: 40979300-41012565 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Enzymes, Essential proteins, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Ligase |
| Biological process | Immunity, Pyrimidine biosynthesis |
Function
This enzyme is involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. This enzyme and its product, CTP, play a crucial role in the proliferation of activated lymphocytes and therefore in immunity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.