Autophagy & Trafficking
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Stress |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 15 genes have a known function matching the annotation |
Why this annotation
ATG2A (autophagy, autophagosome formation) is the top hub, supported by TOM1 (endosome/multivesicular body trafficking, links to autophagy), LITAF (ER/lysosome-associated, regulates TNF-α secretion and trafficking), MTFP1 (mitochondrial fission protein, links mitophagy), PIK3R1 (PI3K p85α, activates class I PI3K opposing autophagy or class III PI3K promoting it), CTPS1 (CTP synthase, cytoophidium/metabolic body linked to lymphocyte activation). KANSL2 (chromatin NuA4 complex), ELOA (elongin A, ubiquitin-mediated regulation). WNT11 and B3GNT2 are peripheral. The module is centered on autophagy and intracellular membrane trafficking.
Genes
ATG2A, B3GNT2, BEST1, CEBPZ, CTPS1, ELOA, KANSL2, LITAF, MTFP1, NSMF, PIK3R1, RIOK3, TOM1, WNT11, ZNF394
Most correlated modules
- AP-1/MEF2 Activation · correlation 0.89
- Post-translational Regulation · correlation 0.88
- Transcription Factor Activity · correlation 0.84
- Stress Granule Response · correlation 0.81
- mRNA Decay Program · correlation 0.80
- mRNA 3' Processing · correlation 0.78
- Co-transcriptional Splicing · correlation 0.76
- TGF-beta Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.