DNA Damage Ubiquitin
Gene co-expression module in Gamma-delta T cells
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 16 genes have a known function matching the annotation |
Why this annotation
Hub FNIP1 (folliculin-interacting protein, AMPK/mTORC1 sensing, metabolic regulation) is the top PageRank gene. ZNF410 (transcription factor), RNF168 (E3 ubiquitin ligase that ubiquitinates H2A-K13/15 at DNA double-strand breaks — key DNA damage response factor), CWC25 (splicing factor), RCOR1 (CoREST epigenetic co-repressor complex), ING3 (PHD-domain protein, chromatin/p53 pathway), UBE2K (ubiquitin E2 conjugating enzyme), TP53INP2 (autophagy/p53), CTPS1 (CTP synthase, critical for T cell proliferation), KLHL18 (Cullin3 adaptor). The module combines DNA damage ubiquitin signaling (RNF168), chromatin repression (RCOR1, ING3), and metabolic sensing (FNIP1, CTPS1). Neighbor M114 also features ubiquitin ligases and p53 regulators, supporting this DNA damage/chromatin regulatory neighborhood.
Genes
ACBD3, CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1, RCOR1, RNF168, SLC35E1, TP53INP2, UBE2K, WDR47, ZFP91, ZNF410
Most correlated modules
- MAPK Kinase Signaling · correlation 0.88
- Ubiquitin-p53 Regulation · correlation 0.86
- Pre-mRNA Splicing · correlation 0.86
- hnRNP Splicing Complex · correlation 0.86
- Transcriptional Coactivation · correlation 0.85
- Chromatin Epigenetic Regulation · correlation 0.84
- Hypoxia Stress Response · correlation 0.83
- TCR Threshold Regulation · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.