RALGAPA1 — Ral GTPase activating protein catalytic subunit alpha 1

RALGAPA1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

RALGAPA1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Immediate early response BCR/AP1/NFKb pathway	CCNT1, CREM, HES4, JMY, JOSD1, KDM4B, NR4A3, PCNX4 +7 more	View in SCUBA
CD4⁺ T cells	TCR early activation TCR/AP1/NFKb pathway	ARIH1, BRAF, CCNT1, CLEC2D, ELL2, EMD, FAM133B, FOSL2 +11 more	View in SCUBA
Endothelial	Inflammatory Angiogenic Activation Inflammation	ALPL, APOL4, ASAP2, CALM1, COMMD2, FAT4, PDGFB, PLS3 +4 more	View in SCUBA
Gamma-delta T cells	DNA Damage Ubiquitin DNA/chromatin regulation	ACBD3, CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RCOR1 +7 more
Macrophages	Ubiquitin Proteasome Regulation Housekeeping	ARIH1, BTAF1, CLASP2, DENND4A, DYRK1A, FBXO11, FBXW7, GATAD2B +8 more	View in SCUBA
Mucosal-associated invariant T cell	RNA Processing Stress RNA processing & translation	DDX3X, ETV3, HSPA5, IVNS1ABP, KDM2A, NAF1, SFPQ, SLC2A3 +3 more
Natural Killer cells	MAPK/AP-1 Signaling Inflammation	B3GNT7, BRAF, FAM177A1, FOSL2, GPBP1, PDE4B, PIK3R1, SDCBP +4 more	View in SCUBA

About the gene

Synonyms	DKFZp667F074, GARNL1, GRIPE, KIAA0884, RalGAPalpha1, Tulip1
Chromosome	14: 35538352-35809304
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins
Molecular function	GTPase activation

Function

Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.