RCOR1 — REST corepressor 1
RCOR1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RCOR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | DNA Damage Ubiquitin DNA/chromatin regulation | ACBD3, CDADC1, CTPS1, CWC25, FNIP1, ING3, KLHL18, RALGAPA1 +7 more | |
| Macrophages | Chromatin Epigenetic Regulation Housekeeping | ABHD17B, ANKH, ARHGAP21, CCNH, CTTNBP2NL, DMXL1, EEIG2, ELF2 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | Transcriptional Repression Immune regulation | ANKRD11, CMIP, MXI1, NR3C1, PELI2, PROSER1, RB1CC1, RFTN1 +7 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8 +5 more |
About the gene
| Synonyms | COREST, KIAA0071, RCOR |
|---|---|
| Chromosome | 14: 102592649-102730561 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chromatin regulator, Repressor |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.