T Cell Survival
Gene co-expression module in Gamma-delta T cells
| Category | T cell maturation |
|---|---|
| Genes | 22 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 14 of 22 genes have a known function matching the annotation |
Why this annotation
This module is dominated by five GIMAP family members (GIMAP1/2/4/5/7), which are hallmark T lymphocyte survival GTPases essential for peripheral T cell homeostasis. Supporting genes include TNFAIP8L2/TNFAIP8 (anti-apoptotic T cell regulators), SIT1 and TRAF3IP3 (T cell signaling adaptors), TNFRSF1A (TNF receptor survival signaling), ICAM2 (lymphocyte adhesion), LPAR5 (T/NK cell migration receptor), and TNFSF10/UCP2. Together these define a resting T cell survival and homeostasis program characteristic of mature, quiescent peripheral T lymphocytes including gd_T cells. Uniform expression across subsets and core coherence support a stable cell-identity program rather than an activation response.
Genes
CASP1, CCDC107, CTU1, GEMIN7, GIMAP1, GIMAP2, GIMAP4, GIMAP5, GIMAP7, ICAM2, LPAR5, MAT2B, MRFAP1L1, S100A11, SARS1, SIT1, TNFAIP8, TNFAIP8L2, TNFRSF1A, TNFSF10, TRAF3IP3, UCP2
Most correlated modules
- T Cell Homeostasis · correlation 0.87
- Effector Cell Migration · correlation 0.84
- Coinhibitory Checkpoint · correlation 0.80
- Lymphocyte Tissue Egress · correlation 0.78
- TCR Proximal Signaling · correlation 0.78
- Death Receptor Apoptosis · correlation 0.77
- T cell Survival · correlation 0.75
- Effector IFN Response · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.