PTPN7 — Protein tyrosine phosphatase non-receptor type 7
PTPN7 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PTPN7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF activation survival Immune regulation | BCL2L1, CD82, CFLAR, CMSS1, EPOP, IL21R, KCNN4, KDM2B +12 more | View in SCUBA |
| CD8⁺ T cells | Tumor mediated exhaustion Exhaustion | ANXA6, CXCL13, GALM, HNRNPLL, IFNG, ITM2A, PDCD1, SARDH +3 more | View in SCUBA |
| Gamma-delta T cells | T Cell Phosphatase Signaling TCR Signaling | AMZ2, ASTE1, DNAJB11, DR1, EFCAB2, IFIT3, PSMD14, SAR1A +4 more | |
| Hematopoietic progenitor cells | Hematopoietic Progenitor Identity Stemness | CD38, DAD1, HSH2D, HYAL3, ITGAE, KIT, MBOAT2, MTHFD2 +2 more | |
| Innate lymphoid cells | Endosomal Trafficking Signaling Immune regulation | ARF1, CCDC85B, CKLF, COMMD8, FAM50A, GDE1, HAX1, IL27RA +16 more | View in SCUBA |
| Monocytes | Inflammatory Metabolic Reprogramming Inflammatory | ACTN1, ADAM8, DGAT2, EAF1, GPAT3, MCTP2, SLC25A37, SLC2A3 | View in SCUBA |
| Mucosal-associated invariant T cell | Splicing Regulation RNA processing & translation | AREG, ARHGAP9, AZIN1, CCNH, CLK1, DDX24, DNAJB6, IL23R +9 more |
About the gene
| Synonyms | HEPTP, LC-PTP |
|---|---|
| Chromosome | 1: 202147013-202161588 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protein phosphatase |
Function
Protein phosphatase that acts preferentially on tyrosine- phosphorylated MAPK1. Plays a role in the regulation of T and B- lymphocyte development and signal transduction.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.