CD180 — CD180 molecule
CD180 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CD180's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B-cell activation signaling B cell maturation | CYB561A3, DAAM1, ETS1, LIMD2, STX7, TERF2IP, UCP2, ZNF106 | View in SCUBA |
| Hematopoietic progenitor cells | Dendritic Cell Progenitor Myeloid development | BLNK, CCDC50, CLEC4A, HDAC9, HERPUD1, IRF8, LY86, NCF1 +1 more |
About the gene
| Synonyms | LY64, Ly78, RP105 |
|---|---|
| Chromosome | 5: 67179613-67196799 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF- kappa-B activation. Also involved in the life/death decision of B-cells (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.