B-cell activation signaling
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 9 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 9 genes have a known function matching the annotation |
Why this annotation
Hub LIMD2 (LIM domain adhesion/migration), TERF2IP (telomere/NF-kB), UCP2 (mitochondrial uncoupling), CYB561A3, STX7 (vesicle trafficking), DAAM1 (formin/actin), CD180/RP105 (B-cell TLR-related receptor regulating BCR), ETS1 (B-cell transcription factor). Mixed module but CD180 and ETS1 anchor it as B-cell activation/maturation signaling. Uniform low expression. No clear single canonical program; metabolic (UCP2) and signaling components. Lean toward B-cell maturation/activation signaling.
Genes
CD180, CYB561A3, DAAM1, ETS1, LIMD2, STX7, TERF2IP, UCP2, ZNF106
Most correlated modules
- Actin cytoskeleton remodeling · correlation 0.86
- Dark-zone GC B-cell · correlation 0.85
- Germinal Center Maturation · correlation 0.84
- B-cell signaling regulators · correlation 0.84
- Somatic Hypermutation · correlation 0.84
- Germinal center B-cell · correlation 0.84
- MHC-II antigen presentation · correlation 0.81
- Naive B-cell identity · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.