AURKA — Aurora kinase A
AURKA belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AURKA's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | G2/M Mitosis Cell cycle | BUB1, CCDC34, CCNB1, CCNB2, CDC20, CDKN3, CENPA, DLGAP5 +7 more | View in SCUBA |
| CD8⁺ T cells | Mitotic Kinase Cascade Cell cycle | CCNB1, CCNB2, CDC20, CDC25B, DEPDC1, FAM72C, FAM72D, KIF20A +6 more | View in SCUBA |
| Goblet cells | Mitotic Spindle Assembly Cell cycle | ARHGAP11A, CDKN3, CENPA, CKAP5, CKS2, FAM83D, KIF14, KNL1 +5 more | View in SCUBA |
| Macrophages | Mitotic Spindle Cell cycle | ANLN, ASPM, BIRC5, CCNA2, CCNB1, CCNB2, CDK1, CDKN2C +14 more | View in SCUBA |
About the gene
| Synonyms | AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7 |
|---|---|
| Chromosome | 20: 56369389-56392337 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Cancer-related genes, Enzymes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
| Biological process | Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis |
Function
Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis. Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Phosphorylates MCRS1 which is required for MCRS1- mediated kinetochore fiber assembly and mitotic progression. Regulates KIF2A tubulin depolymerase activity. Important for microtubule formation and/or stabilization. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint- response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53. Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity. Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin. Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.