KIF20A — Kinesin family member 20A
KIF20A belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KIF20A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Mitotic Kinase Cascade Cell cycle | AURKA, CCNB1, CCNB2, CDC20, CDC25B, DEPDC1, FAM72C, FAM72D +6 more | View in SCUBA |
| Smooth muscle cells | Mitotic Spindle Cell cycle | AURKB, CCNA2, CDCA3, CDK1, MKI67, NUSAP1, PIMREG, SGO1 +4 more | View in SCUBA |
About the gene
| Synonyms | MKLP2, RAB6KIFL |
|---|---|
| Chromosome | 5: 138178719-138187723 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins |
| Molecular function | Motor protein |
| Biological process | Protein transport, Transport |
Function
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end- directed motility
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.