Mitotic Kinase Cascade
Gene co-expression module in CD8⁺ T cells
| Category | Cell cycle |
|---|---|
| Genes | 15 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 15 of 15 genes have a known function matching the annotation |
Why this annotation
All 15 genes are core mitotic regulators, predominantly acting at G2/M entry and mitotic exit. PLK1 and AURKA are the master mitotic kinases; CDC20 activates the APC/C for mitotic exit; NEK2 triggers centrosome separation; CCNB1 and CCNB2 are the canonical mitotic cyclins; CDC25B dephosphorylates CDK1 for G2/M entry; KIF20A (MKLP2) is a kinesin required for cytokinesis; TROAP stabilizes astral microtubules; PSRC1 (ASPM-related) regulates spindle length; KNSTRN (SKAP) links kinetochores to astral microtubules; DEPDC1 and FAM72D/C are mitotic regulators; PIF1 is a helicase active at G2/M. Core coherence and uniform low pct positive (~2.9%) match cycling CD8 T cells. As a close neighbor to M29 and M58, this module represents the G2/M kinase cascade, deepening the resolution of the batch's mitotic cell cycle neighborhood.
Genes
AURKA, CCNB1, CCNB2, CDC20, CDC25B, DEPDC1, FAM72C, FAM72D, KIF20A, KNSTRN, NEK2, PIF1, PLK1, PSRC1, TROAP
Most correlated modules
- G2/M Cell Cycle · correlation 0.95
- Mitotic Spindle · correlation 0.94
- G1/S Entry Checkpoint · correlation 0.92
- Mitosis & Cytokinesis · correlation 0.91
- CDK1-Aurora Kinase Mitosis · correlation 0.91
- FOXM1-driven G2/M · correlation 0.85
- Spindle Bipolarity Cytokinesis · correlation 0.82
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.