Chromatin Transcriptional Regulation
Gene co-expression module in Macrophages
| Category | Housekeeping |
|---|---|
| Genes | 28 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 8 of 28 genes have a known function matching the annotation |
Why this annotation
This module has all weak memberships and unknown coherence, suggesting a poorly defined program. Hub genes include TASOR (HUSH complex, epigenetic silencing), ZMYND8 (chromatin reader/transcriptional repressor), DICER1 (miRNA biogenesis), CLOCK (circadian transcription factor), SP1 (general transcription factor), NFATC3 (transcription factor), DDX17 (RNA helicase/transcriptional coactivator), and XIAP (anti-apoptotic E3 ubiquitin ligase). The mix includes chromatin regulators, RNA processing factors, and transcription factors. CEPT1 is involved in phospholipid synthesis. GIT2 is a GTPase-activating protein. The module lacks a tight single program but the dominant theme among hub genes is chromatin/epigenetic regulation and transcriptional control (TASOR, ZMYND8, CLOCK, SP1, NFATC3, HIPK1). Mild enrichment in mono_mac for some genes. Given the weak coherence and mixed composition, this is best described as a loosely co-regulated transcriptional/epigenetic regulatory module. The neighbor context (M88, M68, M56, M67 all involve RNA processing and chromatin) supports a broad housekeeping/regulatory theme.
Genes
AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10, DDX17, DDX42, DICER1, DYNC1LI2, EDEM3, GIT2, GPRIN3, HIPK1, NFATC3, PDPR, PPIP5K2, SEMA4D, SP1, TASOR, TLR1, TMEM260, WDR11, WDR6, XIAP, ZMYND8
Most correlated modules
- General Cellular Maintenance · correlation 0.97
- TGF-beta Signaling · correlation 0.96
- Splicing Factor Regulation · correlation 0.96
- ER-Golgi Trafficking · correlation 0.95
- RNA Splicing Processing · correlation 0.95
- Endolysosomal Trafficking · correlation 0.95
- Myeloid Innate Signaling · correlation 0.95
- Autophagy Vesicular Trafficking · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.