ARID1A — AT-rich interaction domain 1A
ARID1A belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ARID1A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Pre-mRNA Splicing RNA processing & translation | AKAP7, CEP57, EIF4E, ENOSF1, GGNBP2, HERC5, HNRNPD, KTN1 +8 more | |
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, CARD8, CEPT1, CLOCK, CPSF7, CTNND1, DCAF10, DDX17 +19 more | View in SCUBA |
| Mucosal-associated invariant T cell | Hypoxia-ER Stress Stress | ANKHD1, ARID4B, ATXN7, CEMIP2, CPD, CTDP1, EIF2AK3, ELF1 +5 more |
About the gene
| Synonyms | B120, BAF250, BAF250a, C10rf4, C1orf4, P270, SMARCF1 |
|---|---|
| Chromosome | 1: 26693236-26782104 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Chromatin regulator, DNA-binding |
| Biological process | Neurogenesis, Transcription, Transcription regulation |
Function
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron- specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.