CTNND1 — Catenin delta 1
CTNND1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CTNND1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | Chromatin Transcriptional Regulation Housekeeping | AGO1, ARID1A, CARD8, CEPT1, CLOCK, CPSF7, DCAF10, DDX17 +19 more | View in SCUBA |
| Monocytes | ER Stress Response Stress | CALR, CSTB, HSP90B1, LPAR6, M6PR, MRPS6, PDIA6, PRDX1 +3 more | View in SCUBA |
| Pericytes | TGF-beta Negative Feedback Inflammatory | DAZAP2, EMP1, KAT6A, KBTBD2, KLF7, MLKL, RCAN1, RGS3 +6 more | View in SCUBA |
About the gene
| Synonyms | CTNND, KIAA0384, p120, p120cas, p120ctn |
|---|---|
| Chromosome | 11: 57753243-57819546 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters |
| Biological process | Cell adhesion, Transcription, Transcription regulation, Wnt signaling pathway |
Function
Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Promotes localization and retention of DSG3 at cell- cell junctions, via its interaction with DSG3. Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.