DNASE2 — Deoxyribonuclease 2, lysosomal
DNASE2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNASE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | IFN-gamma Response Inflammatory | ANKRD22, APOL2, ATF5, ATP13A1, CD274, CD300LF, CD40, CD48 +21 more | View in SCUBA |
| Monocytes | Mitochondrial Immune Regulation Mitochondrial & OxPhos | CALHM2, CORO1B, DOK2, NDUFAF3, SIGLEC10, SLC39A1, UCP2 | View in SCUBA |
About the gene
| Synonyms | DNL, DNL2 |
|---|---|
| Chromosome | 19: 12875209-12881595 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Developmental protein, Endonuclease, Hydrolase, Nuclease |
| Biological process | Apoptosis |
Function
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.