Venous EC Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 16 genes have a known function matching the annotation |
Why this annotation
Hub genes CAVIN2 (caveolae biogenesis), LAYN (venous/lymphatic EC marker), SELENOP (antioxidant selenium transport expressed in venous ECs), EPHX1 (xenobiotic/lipid metabolism), RARB (retinoic acid signaling), CEACAM1 (EC adhesion), and CYBA (NADPH oxidase) collectively define a venous endothelial identity with antioxidant and metabolic homeostasis features. The module is significantly downregulated in UC inflammation, consistent with loss of quiescent EC identity during inflammatory activation. GMFG supports actin cytoskeletal regulation in quiescent ECs. This contrasts with neighbor M32 which is upregulated in inflammation.
Genes
CAVIN2, CEACAM1, CYBA, DNMBP, EFCC1, EPHX1, GMFG, HID1, KANK3, LAYN, MBP, MED10, NDRG2, PDE2A, RARB, SELENOP
Most correlated modules
- EC Cytoskeletal Scaffold · correlation 0.84
- Actomyosin Contractility · correlation 0.67
- Venous EC Identity · correlation 0.65
- Inflammatory EC Activation · correlation 0.64
- Inflammatory Angiogenesis · correlation 0.56
- Venous EC Identity · correlation 0.55
- Inflammatory ECM Remodeling · correlation 0.53
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.