CAVIN2 — Caveolae associated protein 2
CAVIN2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CAVIN2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Venous EC Identity Endothelial cell development | CEACAM1, CYBA, DNMBP, EFCC1, EPHX1, GMFG, HID1, KANK3 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Platelet Biogenesis Myeloid development | CCL5, CMTM5, F13A1, GNG11, GP9, MAP3K7CL, NRGN, PF4 +6 more | |
| Lymphatic endothelial | Oxidative Stress Protection Stress | ALDH2, ANAPC16, BCL7C, CCL21, CD320, CRACR2B, FXYD6, GUSB +10 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal lncRNA Activation Activation | AES, C20orf27, CYTOR, LHFPL6, MIR4435-2HG, MSC-AS1, RAPGEF2, SEPT11 +2 more | View in SCUBA |
About the gene
| Synonyms | cavin-2, PS-p68, SDPR, SDR |
|---|---|
| Chromosome | 2: 191834310-191847088 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Plasma proteins, Predicted intracellular proteins |
Function
Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.