DTX4 — Deltex E3 ubiquitin ligase 4
DTX4 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DTX4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, F11R, GABRA2, KAZN +5 more | View in SCUBA |
About the gene
| Synonyms | KIAA0937, RNF155 |
|---|---|
| Chromosome | 11: 59171430-59208588 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Notch signaling pathway, Ubl conjugation pathway |
Function
Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.