CCL11 Secretory Fibroblast
Gene co-expression module in Fibroblasts
| Category | ECM production |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 14 genes have a known function matching the annotation |
Why this annotation
Hub genes COL18A1 (collagen XVIII, basement membrane collagen with endostatin domain), QSOX1 (quiescin sulfhydryl oxidase, ECM crosslinking/disulfide bond formation in secreted proteins), CCL11 (eotaxin-1, chemokine for eosinophil recruitment), NR2F1 (COUP-TF1, nuclear receptor transcription factor marking specific fibroblast subsets), KAZN (kazrin, desmosome-associated), TFPI2 (tissue factor pathway inhibitor 2, ECM-associated serine protease inhibitor), COL16A1 (collagen XVI, fibril-associated collagen), ARHGAP24 (Rho GAP), F11R (JAM-A, tight junction/adhesion), and ANK3 (ankyrin-3, cytoskeletal) define a program combining ECM collagen production with chemokine secretion. CCL11 is notable for eosinophil recruitment. NR2F1 marks a specific fibroblast subpopulation. MAPK10 (JNK3), GABRA2 (GABA receptor), DTX4 (Deltex E3 ligase), and PLXDC2 (plexin domain) are peripheral. The module is downregulated in CD inflammation and recovers in remission. Neighbor to M119 and M65.
Genes
ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2, KAZN, MAPK10, NR2F1, PLXDC2, QSOX1, TFPI2
Most correlated modules
- Homeostatic Fibroblast Identity · correlation 0.82
- Interferon Response · correlation 0.81
- Homeostatic Fibroblast State · correlation 0.81
- Stromal Niche Signaling · correlation 0.79
- BMP-ECM Fibroblast · correlation 0.75
- Elastic Fiber ECM · correlation 0.72
- Subepithelial Fibroblast · correlation 0.70
- Inflammatory Fibroblast Activation · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.