ARHGAP24 — Rho GTPase activating protein 24

ARHGAP24 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ARHGAP24's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Adhesion/Migration migration & adhesion	ADAM28, ADAMTS6, ARHGAP5, CHPT1, CLMN, CMTR2, FCMR, JAM3 +11 more	View in SCUBA
Fibroblasts	CCL11 Secretory Fibroblast ECM production	ANK3, CCL11, COL16A1, COL18A1, DTX4, F11R, GABRA2, KAZN +5 more	View in SCUBA
Glial cells	Glial Neural Scaffolding Cytoskeletal	AKAP6, COL5A3, EIF4G2, NFIX, PPP1R12B, SCAF11, SEMA6D, USP53	View in SCUBA
Neutrophils	Granulopoiesis Program Developmental	ARID1B, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8, PHIP +5 more

About the gene

Synonyms	DKFZP564B1162, FilGAP, FLJ33877
Chromosome	4: 85475150-86002668
Predicted location	Intracellular
Essential gene	No
Protein class	Predicted intracellular proteins
Molecular function	Developmental protein, GTPase activation
Biological process	Angiogenesis, Differentiation

Function

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.