GABRA2 — Gamma-aminobutyric acid type A receptor subunit alpha2
GABRA2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GABRA2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Long-gene Nuclear Transcripts Technical artifact | ABCA10, ABCA5, ADCY9, EXOC6B, IL6R, INSR, MAGI1, MBNL1 +6 more | View in SCUBA |
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, CCL11, COL16A1, COL18A1, DTX4, F11R, KAZN +5 more | View in SCUBA |
About the gene
| Chromosome | 4: 46243548-46475230 |
|---|---|
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Chloride channel, Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Function
Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.