CCL11 — C-C motif chemokine ligand 11
CCL11 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CCL11's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, COL16A1, COL18A1, DTX4, F11R, GABRA2, KAZN +5 more | View in SCUBA |
| Pericytes | Stromal ECM Production ECM production | ABCA8, CFD, CTSK, DCN, FBLN1, LUM, MFAP4, VCAN | View in SCUBA |
About the gene
| Synonyms | eotaxin, MGC22554, SCYA11 |
|---|---|
| Chromosome | 17: 34285742-34288334 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Human disease related genes, Predicted secreted proteins |
| Molecular function | Cytokine |
| Biological process | Chemotaxis, Inflammatory response |
Function
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.