EMILIN1 — Elastin microfibril interfacer 1
EMILIN1 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
EMILIN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL3A1 +12 more | View in SCUBA |
| Smooth muscle cells | Collagen Biosynthesis ECM remodeling | CALU, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A2 +4 more | View in SCUBA |
About the gene
| Synonyms | DKFZp586M121, EMILIN, gp115 |
|---|---|
| Chromosome | 2: 27078615-27086403 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Involved in elastic and collagen fibers formation. It is required for EFEMP2 deposition into the extracellular matrix, and collagen network assembly and cross-linking via protein-lysine 6- oxidase/LOX activity. May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved in the processes that regulate vessel assembly. Has cell adhesive capacity
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.