COL3A1 — Collagen type III alpha 1 chain
COL3A1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL3A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL5A1 +12 more | View in SCUBA |
| Pericytes | Fibrillar Collagen Production ECM production | COL1A1, COL1A2, COL5A1, COL6A1, COL6A2, COL6A3, GGT5, PCOLCE +1 more | View in SCUBA |
| Smooth muscle cells | Collagen Biosynthesis ECM remodeling | CALU, COL1A1, COL1A2, COL4A1, COL4A2, COL6A1, COL6A2, EMILIN1 +4 more | View in SCUBA |
About the gene
| Synonyms | EDS4A |
|---|---|
| Chromosome | 2: 188974373-189012746 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
Function
Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.