ANTXR1 — ANTXR cell adhesion molecule 1
ANTXR1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANTXR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Collagen ECM Production ECM production | AEBP1, ANGPTL2, CERCAM, CLTC, COL1A1, COL1A2, COL3A1, COL5A1 +12 more | View in SCUBA |
| Glial cells | Reactive Glial Activation Activation | ANP32B, CTSD, FAM20C, GNG11, MAP1B, PKM, PTEN, RASEF +2 more | View in SCUBA |
| Smooth muscle cells | Mesenchymal Adhesion Program Migration & adhesion | BAG2, CDH11, COL12A1, CTSB, FHL3, FSTL3, HEPH, PIM1 +6 more | View in SCUBA |
About the gene
| Synonyms | ATR, FLJ10601, FLJ21776, TEM8 |
|---|---|
| Chromosome | 2: 69013176-69249327 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
Function
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis. (Microbial infection) Mediates cell entry of Seneca Valley virus (SVV) when glycosylated
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.