AEBP1 — AE binding protein 1
AEBP1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AEBP1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Collagen ECM Production ECM production | ANGPTL2, ANTXR1, CERCAM, CLTC, COL1A1, COL1A2, COL3A1, COL5A1 +12 more | View in SCUBA |
| Glial cells | Reactive Glial Activation Activation | ATP5F1E, EEA1, F2R, FN1, IFI16, POLR2L, PRSS23, PSMA4 | View in SCUBA |
| Pericytes | Pericyte ECM Production ECM production | CALD1, COL14A1, GUCY1B1, LURAP1L, PMP22, SDC2, TPPP3, VCL | View in SCUBA |
About the gene
| Synonyms | ACLP |
|---|---|
| Chromosome | 7: 44104345-44114562 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins |
| Molecular function | Calmodulin-binding, DNA-binding, Repressor |
| Biological process | Transcription, Transcription regulation |
Function
As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.