Collagen Biosynthesis
Gene co-expression module in Smooth muscle cells
| Category | ECM remodeling |
|---|---|
| Genes | 13 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
A textbook fibrillar/basement-membrane collagen synthesis module: COL1A1/COL1A2/COL3A1 (interstitial fibrillar), COL4A1/COL4A2 (basement membrane), COL6A1/COL6A2 (microfibrillar), plus FN1, EMILIN1, FSTL1 and the collagen-processing chaperone CALU, together with the matrix receptors ITGB1 and VCL. Core coherence and uniform expression indicate a genuine synthetic/myofibroblast-like ECM production program in colonic smooth muscle cells, and it anchors the ECM-centric neighborhood (M27 matrisome regulators, M26 fibroblast matrisome).
Genes
CALU, COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A2, EMILIN1, FN1, FSTL1, ITGB1, VCL
Most correlated modules
- Matrisome Regulators · correlation 0.89
- Collagen-Laminin Deposition · correlation 0.86
- Matrix-integrin interaction · correlation 0.85
- Adhesion Activation · correlation 0.82
- Fibroblast Matrisome · correlation 0.76
- Wnt-Hedgehog Niche · correlation 0.76
- Notch-TGFbeta Signaling · correlation 0.75
- Mesenchymal Adhesion Program · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.