GNE — Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GNE belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNE's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Goblet cells | Goblet Secretory Identity Mucus production & secretion | CREB3L1, ENTPD8, FKBP11, ITLN1, NPDC1, REP15, SH3BGRL3, SLC50A1 +4 more | View in SCUBA |
About the gene
| Synonyms | IBM2, Uae1 |
|---|---|
| Chromosome | 9: 36214441-36277042 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Allosteric enzyme, Hydrolase, Kinase, Multifunctional enzyme, Transferase |
Function
Bifunctional enzyme that possesses both UDP-N- acetylglucosamine 2-epimerase and N-acetylmannosamine kinase activities, and serves as the initiator of the biosynthetic pathway leading to the production of N-acetylneuraminic acid (NeuAc), a critical precursor in the synthesis of sialic acids. By catalyzing this pivotal and rate-limiting step in sialic acid biosynthesis, this enzyme assumes a pivotal role in governing the regulation of cell surface sialylation, playing a role in embryonic angiogenesis. Sialic acids represent a category of negatively charged sugars that reside on the surface of cells as terminal components of glycoconjugates and mediate important functions in various cellular processes, including cell adhesion, signal transduction, and cellular recognition.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.