SH3BGRL3 — SH3 domain binding glutamate rich protein like 3

SH3BGRL3 belongs to a gene co-expression module in 15 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

SH3BGRL3's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Actin Cytoskeleton Cytoskeletal	COTL1, GNAI2, HIGD2A, MOB1A, MPG, MYL12A, MYL12B, NDUFB5 +8 more	View in SCUBA
CD4⁺ T cells	Actin Cytoskeleton Cytoskeletal	ABRACL, CAPZB, CD53, CFL1, CKLF, DRAP1, GUK1, MYL12B +6 more	View in SCUBA
CD8⁺ T cells	Gut Tissue Residency Gut residence	ALOX5AP, C4orf3, CAPN2, CD164, CD3D, CD7, CD99, CLIC3 +9 more	View in SCUBA
Endothelial	Actin Cytoskeletal Remodeling Cytoskeletal	ABCE1, ANXA2, CAMKK2, CORO1C, DBN1, EIF3J, MIF, PPP1R14B +3 more	View in SCUBA
Fibroblasts	Proteolytic Fibroblast State ECM remodeling	ANXA2, CTSK, EMP3, LGALS3, MPZL1, PCOLCE, ROBO1, S100A10 +3 more	View in SCUBA
Gamma-delta T cells	Effector IFN Response cytotoxicity	AGTRAP, ANXA1, B2M, CYBA, EMP3, FXYD5, GZMM, IFITM1 +9 more
Glial cells	Mitochondrial Housekeeping Mitochondrial & OxPhos	ATP5F1D, ATP6V1G1, COX7C, GNG5, RAN, SEM1, ST3GAL4, SUB1 +3 more	View in SCUBA
Goblet cells	Goblet Secretory Identity Mucus production & secretion	CREB3L1, ENTPD8, FKBP11, GNE, ITLN1, NPDC1, REP15, SLC50A1 +4 more	View in SCUBA
Innate lymphoid cells	Antigen Processing MHC-I Immune regulation	CMTM6, GUK1, IL2RB, IL4R, MYL12A, PAXX, PSMA5, PSMB8 +8 more	View in SCUBA
Lymphatic endothelial	Oxidative Stress Response Stress	AP2S1, APRT, ATOX1, C4orf3, FKBP1A, GADD45GIP1, GSTP1, RABAC1 +1 more	View in SCUBA
Macrophages	Oxidative Metabolic Program Mitochondrial & OxPhos	ACADM, CA2, CALM3, CAPG, COQ2, CSRP1, CSTB, DENND2D +29 more	View in SCUBA
Mucosal-associated invariant T cell	Cytotoxic Lymphocyte Program cytotoxicity	ANXA11, CDKN2D, CYB5A, EMP3, ETHE1, FLT3LG, GLIPR2, LDHB +9 more
Natural Killer cells	Gut-Homing NK Maturation Gut residency	ANXA2, BIN1, DHRS7, HECA, IFI27L2, ITGB7, KLF9, LGALS1 +5 more	View in SCUBA
Neutrophils	S100 Alarmin Response Inflammatory	CD177, H2AC6, METTL9, MS4A6A, RBP7, S100A12, S100A4, S100A6
Smooth muscle cells	BMP-ID3 Matricellular Development	ANXA1, DKK3, HAPLN3, ID3, SMOC2, STOM, TAGLN2	View in SCUBA

About the gene

Chromosome	1: 26280086-26281522
Predicted location	Intracellular
Essential gene	No
Protein class	Plasma proteins, Predicted intracellular proteins

Function

Could act as a modulator of glutaredoxin biological activity (Probable). May play a role in cytoskeleton organization.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.