ENTPD8 — Ectonucleoside triphosphate diphosphohydrolase 8
ENTPD8 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ENTPD8's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Enterocytes | Brush border lipid handling Absorption | ABCG1, ABHD12, ARL14, CDHR2, IDS, PNPLA2, RAI14, SEMA3G +2 more | View in SCUBA |
| Goblet cells | Goblet Secretory Identity Mucus production & secretion | CREB3L1, FKBP11, GNE, ITLN1, NPDC1, REP15, SH3BGRL3, SLC50A1 +4 more | View in SCUBA |
About the gene
| Synonyms | NTPDase-8, UNQ2492 |
|---|---|
| Chromosome | 9: 137434364-137441816 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase |
Function
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.