HELB — DNA helicase B
HELB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HELB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | DNA repair/replication DNA/chromatin regulation | ACAP2, BROX, CCDC88C, CKAP2, EPM2AIP1, FOXO3, HAUS3, KMT2C +4 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Mucosal-associated invariant T cell | Nuclear regulatory housekeeping Housekeeping | ATXN2, BAZ1B, CCDC90B, CD164, CREB1, GIGYF2, HNRNPA2B1, PHIP +6 more |
About the gene
| Chromosome | 12: 66302493-66343643 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Helicase, Hydrolase |
| Biological process | DNA damage, DNA repair |
Function
5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.