PHIP — Pleckstrin homology domain interacting protein
PHIP belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PHIP's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin Regulation DNA/chromatin regulation | ADI1, ASXL2, BTG3, CASP8, CHD3, CTSS, CWF19L2, DENND2D +17 more | View in SCUBA |
| Gamma-delta T cells | Nuclear Pore Organization Housekeeping | AIDA, DHX8, H4C6, LARP1, LBR, MPRIP, MTR, NNT +14 more | |
| Innate lymphoid cells | Pyruvate Metabolism Metabolism | ABCB1, ADI1, ARID1B, ATF7IP2, CFAP298, EIF2AK2, HNRNPH3, MINDY2 +10 more | View in SCUBA |
| Macrophages | Chromatin Regulatory Genes Housekeeping | ACAP2, ARID4A, ATRX, BPTF, BRD10, BRD4, EP300, ERBIN +31 more | View in SCUBA |
| Mucosal-associated invariant T cell | Nuclear regulatory housekeeping Housekeeping | ATXN2, BAZ1B, CCDC90B, CD164, CREB1, GIGYF2, HELB, HNRNPA2B1 +6 more | |
| Neutrophils | Granulopoiesis Program Developmental | ARHGAP24, ARID1B, B4GALT5, CSGALNACT1, FLI1, IQGAP2, LYST, PDZD8 +5 more |
About the gene
| Synonyms | BRWD2, DCAF14, FLJ20705, ndrp, WDR11 |
|---|---|
| Chromosome | 6: 78934419-79078287 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins |
Function
Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.