CXCR6 — C-X-C motif chemokine receptor 6
CXCR6 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CXCR6's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Effector Immune Activation Immune regulation | ABI3, APBB1IP, ASB2, BUB3, CALCOCO2, CASP4, COMMD7, CTSD +7 more | View in SCUBA |
| CD8⁺ T cells | Terminal Exhaustion Exhaustion | ACP5, CARD16, CASP1, CD2, CD247, CD8A, CD8B, CHST12 +6 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, DGKA +22 more | |
| Mucosal-associated invariant T cell | MAIT Tissue Residence Tissue residence | ANAPC16, ARHGDIB, ATP5IF1, CD3E, CD53, CD99, CTSD, ECH1 +7 more |
About the gene
| Synonyms | BONZO, CD186, STRL33, TYMSTR |
|---|---|
| Chromosome | 3: 45940933-45948351 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | CD markers, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.