Nuclear regulatory housekeeping
Gene co-expression module in Mucosal-associated invariant T cell
| Category | Housekeeping |
|---|---|
| Genes | 15 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes BAZ1B (chromatin remodeling, ISWI complex), XPO1 (nuclear export), USP48 (deubiquitinase), STK4 (MST1 kinase, Hippo pathway), CREB1 (transcription factor), SENP6 (SUMO protease), ATXN2 (RNA granule/stress), GIGYF2 (translational repression), PHIP (chromatin reader), HELB (helicase), and HNRNPA2B1 (RNA binding) point to a diverse housekeeping program involving nuclear transport, chromatin regulation, ubiquitin/SUMO modification, and RNA processing. The uniform expression across all subsets and moderate-to-strong coherence support a general cellular maintenance/housekeeping program rather than a specialized immune or stress program. No strong single pathway dominates, but the cluster of nuclear regulatory factors (XPO1, BAZ1B, SENP6, USP48, CREB1) forms a coherent chromatin/nuclear regulation axis.
Genes
ATXN2, BAZ1B, CCDC90B, CD164, CREB1, GIGYF2, HELB, HNRNPA2B1, PHIP, PPIP5K2, SENP6, STK4, TRANK1, USP48, XPO1
Most correlated modules
- Chemokine Receptor Migration · correlation 0.87
- Endosomal Actin Organization · correlation 0.85
- NF-κB Immune Survival · correlation 0.84
- Chromatin Maintenance State · correlation 0.83
- T cell Homeostasis · correlation 0.82
- Integrin Actin Adhesion · correlation 0.81
- SWI/SNF Chromatin Remodeling · correlation 0.80
- Immune Synapse Signaling · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.