CASK — Calcium/calmodulin dependent serine protein kinase
CASK belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CASK's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | IL10/cytokine signaling Immune regulation | CCDC141, FOXN3, IL10RA, IL7, SLC12A6, STAMBPL1, TMEM154, TNFRSF13B +4 more | View in SCUBA |
| Enterocytes | Long-gene intronic signal Technical artifact | ASCC3, KCNQ1, LGR4, MAP3K5, MECOM, MID1, PPP1R9A, RALGAPA2 +5 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CCR5, CD84, CDC14A, CXCR6, DGKA +22 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CITED2, GLUL, GNAS, HECA, IGFBP7, IQGAP1 +19 more | View in SCUBA |
| Natural Killer cells | ILC1/NK Cytotoxic Cytotoxicity | A1BG, CLDND1, EIF3G, GZMK, ITM2C, KLRB1, NCF1, PDCD4 +4 more | View in SCUBA |
About the gene
| Synonyms | CAGH39, FGS4, LIN2, TNRC8 |
|---|---|
| Chromosome | X: 41514934-41923554 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase |
Function
Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D- aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.