HRH2 — Histamine receptor H2
HRH2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HRH2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Naive T cell T cell development | AIF1, AK5, APBA2, BEND5, BEX2, C1orf162, CBR3, CYSLTR1 +21 more | View in SCUBA |
| Fibroblasts | ICC niche interactaion Gut motility | ABCC9, ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX +10 more | View in SCUBA |
| Neutrophils | Immature Granulocyte Progenitor Developmental | ACSL4, AMPH, AVIL, CDC123, ENSG00000282804, HAL, MAOA, MPZL1 +3 more | |
| Smooth muscle cells | Secondary Response Genes Stress | ABHD2, BCL6, CSRNP1, ECM2, GADD45A, LITAF, MAT2A, MCL1 +3 more | View in SCUBA |
About the gene
| Chromosome | 5: 175658030-175710756 |
|---|---|
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
Function
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.