Secondary Response Genes
Gene co-expression module in Smooth muscle cells
| Category | Stress |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes are delayed/secondary response genes downstream of AP-1/NF-kB signaling: MCL1 (survival), LITAF (LPS-induced TNF factor), BCL6, CSRNP1 (axud1, a serum-response TF), GADD45A (stress/growth arrest), MAT2A and ABHD2 (stress-inducible metabolic genes), plus GPCR receptors coupling to the same pathway (S1PR3, HRH2) and SMC/ECM genes (RASL12, ECM2) reflecting the smooth-muscle context. Expression is uniform and low-to-moderate with no lineage-restricted subset, arguing against contamination. Its network neighbors (M79 immediate-early, M91 NF-kB/IER, M28 NR4A-ADAMTS) place it in the late/secondary wave of the same activation cascade, most plausibly initiated by tissue dissociation/handling stress.
Genes
ABHD2, BCL6, CSRNP1, ECM2, GADD45A, HRH2, LITAF, MAT2A, MCL1, RASL12, S1PR3, TPCN1
Most correlated modules
- Vasoconstrictor Signaling · correlation 0.85
- Contractile SMC Identity · correlation 0.75
- Chaperonin heat-shock · correlation 0.75
- Pericyte Basement Membrane · correlation 0.75
- NR4A-ADAMTS Activation · correlation 0.74
- Vascular Matrix Secretion · correlation 0.73
- Mural/Pericyte Identity · correlation 0.73
- Immediate Early Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.