MCL1 — MCL1 apoptosis regulator, BCL2 family member

MCL1 belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

MCL1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	Activation/Migration BCR/AP1/NFKb pathway	AHNAK, DUSP10, DUSP8, GGA1, GPR183, GPR65, IDS, KLF6 +11 more	View in SCUBA
CD4⁺ T cells	Effector activation NFkB TCR/AP1/NFKb pathway	ADAM19, AHR, ARFGAP3, ATF5, BHLHE40, CGAS, DUSP5, ETF1 +23 more	View in SCUBA
CD8⁺ T cells	Tc17 Survival Program Tc17 program	CCL20, DDX5, IRF1, MAF, SAT1, TNFAIP3, TNFRSF4	View in SCUBA
Gamma-delta T cells	ER Proteotoxic Stress Stress	ARL4A, BCAS2, CCDC59, CSRNP1, CYCS, EIF5, EXOSC6, FOSB +13 more
Glial cells	Integrated Stress Response Stress	ANKRD37, BAG3, CDKN1A, CSRNP1, DDIT3, EGR2, EGR3, MIDN +3 more	View in SCUBA
Goblet cells	Stress Survival Response Stress	EPHA2, ERRFI1, EZR, KLF6, LDLR, LMNA, NEDD9, SQSTM1 +3 more	View in SCUBA
Innate lymphoid cells	NR4A Activation Response activation	ALG13, ARL4A, BCAS2, CASP3, CHMP1B, CREM, DDX24, DLL1 +16 more	View in SCUBA
Macrophages	Splicing Factor Regulation Housekeeping	ARAP1, CCNL1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220 +12 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CCNL1, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1 +7 more
Neutrophils	C5aR Complement Activation Innate immunity	ADGRG3, C5AR1, CD55, ITPRIP, LAPTM5, PFKFB3, PTPRE, RYBP +3 more
Smooth muscle cells	Secondary Response Genes Stress	ABHD2, BCL6, CSRNP1, ECM2, GADD45A, HRH2, LITAF, MAT2A +3 more	View in SCUBA

About the gene

Synonyms	BCL2L3, Mcl-1
Chromosome	1: 150560895-150579738
Predicted location	Intracellular, Membrane
Essential gene	Yes
Protein class	Cancer-related genes, Essential proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Developmental protein
Biological process	Apoptosis, Differentiation

Function

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.