Mitochondrial Translation
Gene co-expression module in Gamma-delta T cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 20 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include COX7A2L (cytochrome c oxidase Complex IV subunit), UQCR10 (ubiquinol-cytochrome c reductase, Complex III), NDUFC1 (NADH dehydrogenase Complex I), MRPL36/MRPS10 (mitoribosome), MTIF3 (mitochondrial translation initiation factor), PHB1 (prohibitin, mitochondrial membrane), TIMM8B (translocase of inner mitochondrial membrane). Supporting genes: PYCR2 (mitochondrial proline synthesis), EGLN2 (prolyl hydroxylase/HIF pathway), PRMT1 (arginine methyltransferase). This module emphasizes mitochondrial translation and multi-complex OxPhos components, with mitoribosomal and import machinery. IL10RB is a peripheral outlier. Neighbor context supports mitochondrial housekeeping theme across the batch.
Genes
ABRACL, COX7A2L, DNAJC7, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36, MRPS10, MTIF3, NDUFC1, NOP10, PHB1, PRMT1, PYCR2, RASSF7, TIMM8B, TMEM134, UQCR10, YIPF4
Most correlated modules
- Mitoribosome Small Subunit · correlation 0.93
- Mitochondrial Housekeeping · correlation 0.90
- Chaperone Protein Folding · correlation 0.90
- Complex I Assembly · correlation 0.88
- Oxidative Phosphorylation · correlation 0.84
- T Cell Homeostasis · correlation 0.84
- General Housekeeping Mixed · correlation 0.84
- Mitochondrial Dynamics · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.