DNAJC7 — DnaJ heat shock protein family (Hsp40) member C7
DNAJC7 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DNAJC7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | mRNA splicing RNA processing | ANAPC5, C11orf58, C1orf43, DDX46, HSPA4, LSM14A, LUC7L3, MRPL47 +8 more | View in SCUBA |
| Gamma-delta T cells | Mitochondrial Translation Mitochondrial & OxPhos | ABRACL, COX7A2L, EGLN2, FAM217B, IL10RB, MPLKIP, MRPL36, MRPS10 +11 more | |
| Innate lymphoid cells | Mitochondrial Translation Mitochondrial & OxPhos | ABCF1, ARGLU1, ATG12, BAG1, C1orf35, CHCHD1, CHMP5, EIF2S2 +37 more | View in SCUBA |
| Macrophages | RNA Splicing Regulation Housekeeping | ABCF1, CDC42SE1, CDC5L, CDV3, CEBPZ, DYNC1LI1, FGFR1OP2, GNL3 +13 more | View in SCUBA |
About the gene
| Synonyms | TPR2, TTC2 |
|---|---|
| Chromosome | 17: 41976421-42021376 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Chaperone |
Function
Acts as a co-chaperone regulating the molecular chaperones HSP70 and HSP90 in folding of steroid receptors, such as the glucocorticoid receptor and the progesterone receptor. Proposed to act as a recycling chaperone by facilitating the return of chaperone substrates to early stages of chaperoning if further folding is required. In vitro, induces ATP-independent dissociation of HSP90 but not of HSP70 from the chaperone-substrate complexes. Recruits NR1I3 to the cytoplasm (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.