INO80 — INO80 complex ATPase subunit
INO80 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
INO80's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Macrophages | DNA Damage Response Stress | APAF1, ARHGAP35, ATP11C, ATR, CDC42SE2, CENATAC, CEP192, CEP85L +19 more | View in SCUBA |
About the gene
| Synonyms | hINO80, INO80A, INOC1, KIAA1259 |
|---|---|
| Chromosome | 15: 40978880-41116280 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
| Molecular function | Actin-binding, DNA-binding, Hydrolase |
| Biological process | Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, Host-virus interaction, Mitosis |
Function
ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV- damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.