CCNL1 — Cyclin L1

CCNL1 belongs to a gene co-expression module in 13 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CCNL1's module in each cell type

Cell type	Module	Shares the module with
CD19⁺ B cells	mRNA Splicing RNA processing	AFF4, ARL6IP1, CALR, CLK1, DDX3X, DDX5, EIF4A2, HSPA5 +7 more	View in SCUBA
CD4⁺ T cells	mRNA Splicing Processing RNA processing	ANXA2R, APOL3, BTN3A1, CHCHD7, CMPK1, DDX5, EIF4A2, EIF5 +7 more	View in SCUBA
Endothelial	Integrated Stress Response Stress	ARL5B, ATF3, CD83, CDKN1A, DDIT3, ICAM4, IRF1, KDM6B +3 more	View in SCUBA
Enterocytes	Junctional Hippo/TGF-beta signaling Migration & adhesion	AFDN, BACH1, DAPK2, DST, PELI2, SMAD3, UACA, WWC1	View in SCUBA
Fibroblasts	Heat Shock Response Stress	BCLAF1, CHORDC1, CLK1, FAM133B, GADD45B, HSPH1, IER5, MIDN +5 more	View in SCUBA
Gamma-delta T cells	Ubiquitin-p53 Regulation Protein processing & ER	ATXN7, DCTN4, FNBP1, HERPUD2, MOB4, RBBP6, RNF139, TP53BP2 +4 more
Glial cells	Integrated Stress Response Stress	ATF3, DNAJA1, DUSP1, HSPA8, HSPH1, KLF4, MAFF, NR4A1 +2 more	View in SCUBA
Goblet cells	NF-κB Stress Response Stress	ATF3, EGR3, IER3, MAFF, MYADM, NFKBIA, NR4A1, RHOB +1 more	View in SCUBA
Innate lymphoid cells	Immediate Early Response activation	ATF3, BRD2, BTG2, DDX3X, DNAJA1, EGR1, EIF4A3, EIF5 +8 more	View in SCUBA
Lymphatic endothelial	Notch TGF-β Endothelial endothelial development	ARF6, ARL4C, C16orf87, CLK1, DEDD2, ELOC, GPBP1, HEY1 +11 more	View in SCUBA
Macrophages	Splicing Factor Regulation Housekeeping	ARAP1, CELF1, CLK1, FAM53C, IFRD1, INPPL1, KIDINS220, MAN2C1 +12 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Activation T cell maturation	BTG2, CD69, CD83, CHMP1B, CYCS, DNAAF2, DNAJA1, FOSB +7 more
Smooth muscle cells	NF-kB Stress Response Stress	BHLHE40, FADS3, HSP90AB1, IER3, MIDN, NFKBIZ, PPP1R15A, THBS1 +1 more	View in SCUBA

About the gene

Synonyms	ania-6a
Chromosome	3: 157146508-157160760
Predicted location	Intracellular
Essential gene	Yes
Protein class	Essential proteins, Predicted intracellular proteins
Molecular function	Cyclin
Biological process	Host-virus interaction, Transcription, Transcription regulation

Function

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). Inhibited by the CDK-specific inhibitor CDKN1A/p21. May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto- oncogene in head and neck squamous cell carcinomas (HNSCC).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.