ITPKB — Inositol-trisphosphate 3-kinase B
ITPKB belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITPKB's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NFAT activation TCR/AP1/NFKb pathway | AHI1, ASAP1, BCAT1, BICDL1, CPM, CYP7B1, ETV6, FAM107B +13 more | View in SCUBA |
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, KITLG, LIMCH1, MALT1 +4 more | View in SCUBA |
| Macrophages | MAPK Stress Kinase Inflammatory | ARHGAP26, BRAF, BTBD9, CRY1, CYTH3, EIF2AK3, ESYT2, EXT1 +12 more | View in SCUBA |
About the gene
| Synonyms | IP3-3KB, IP3KB |
|---|---|
| Chromosome | 1: 226631690-226739323 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Calmodulin-binding, Kinase, Transferase |
Function
Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5- trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.