MALT1 — MALT1 paracaspase
MALT1 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MALT1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | NF-kB Chromatin Regulation DNA/chromatin regulation | ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, ITPKB, KITLG, LIMCH1 +4 more | View in SCUBA |
| Gamma-delta T cells | mRNA Splicing Regulation RNA processing & translation | ARF6, BTG3, CAPN7, CDV3, CELF2, CNBD2, CUL3, CYTIP +18 more | |
| Innate lymphoid cells | ILC3 identity Differentiation | BHLHE40, BRD4, CASK, CITED2, GLUL, GNAS, HECA, IGFBP7 +19 more | View in SCUBA |
| Macrophages | Autophagy Vesicle Trafficking Lysosomal & pahgocytosis | ADNP2, AGO2, AP1G1, ARFGAP3, ATG2A, BANP, CHD1, CHD2 +26 more | View in SCUBA |
| Monocytes | Monocyte Immune Tolerance Tissue adaptation | ATP1B3, CTSL, EMP1, FCER1G, FTH1, HAVCR2, INSIG1, TIMP1 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Tissue Residency Tissue residence | ACSL1, AMFR, CRACDL, DHX36, HES4, IRF8, ITGAE, LZTFL1 +8 more |
About the gene
| Synonyms | MLT, PCASP1 |
|---|---|
| Chromosome | 18: 58671465-58754477 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins |
| Molecular function | Hydrolase, Protease |
| Biological process | Immunity, Ubl conjugation pathway |
Function
Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation (By similarity). Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.