NF-kB Chromatin Regulation
Gene co-expression module in Endothelial
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 13 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 13 genes have a known function matching the annotation |
Why this annotation
Hub genes include MLLT6 (AF17, chromatin/transcription regulator), IKBKB (IKK-beta, NF-kB pathway kinase), MALT1 (paracaspase, NF-kB signaling), SATB1 (chromatin organizer/transcription factor), HOXB3 (HOX transcription factor), LIMCH1 (cytoskeletal/actin), SORBS2 (sorbin, actin cytoskeleton), ARHGEF3 (Rho-GEF), DGKE (diacylglycerol kinase epsilon, lipid signaling), ITPKB (inositol trisphosphate kinase B, IP3 signaling), KITLG (stem cell factor), and SUN1 (nuclear envelope). The module is downregulated in inflammation and recovers in remission. The combination of NF-kB pathway components (IKBKB, MALT1), chromatin regulators (MLLT6, SATB1), and cytoskeletal genes suggests a transcriptional/signaling program maintaining endothelial identity. Neighbor context: shares the inflammation-downregulated, remission-restored pattern with M29, suggesting related homeostatic programs.
Genes
ARHGEF3, DGKE, HLA-E, HOXB3, IKBKB, ITPKB, KITLG, LIMCH1, MALT1, MLLT6, SATB1, SORBS2, SUN1
Most correlated modules
- Caveolae-mediated Transcytosis · correlation 0.75
- Vascular EC Identity · correlation 0.75
- Endothelial Barrier Homeostasis · correlation 0.72
- EC Quiescence Identity · correlation 0.71
- MHC Class I Presentation · correlation 0.65
- Capillary Endothelial Identity · correlation 0.60
- Glucocorticoid Response · correlation 0.59
- Glucocorticoid Response · correlation 0.58
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.